Purpose: Optical brain pulse monitoring (OBPM: Cyban Pty. Ltd) is an innovative neuromonitoring technology using the near-infrared light to identify cerebrovascular changes in patients at risk of both primary and secondary brain injury. This review collates patient demographic data and user knowledge from our experience operating the device in the clinical research setting. 
Patients and methods: We performed a retrospective review of data from patients who received non-invasive OBPM between October 2020 to August 2024. 
Results: Five clinical studies conducted at six global sites used OBPM on 195 patients without any device-related adverse events. OBPM was used successfully in a wide-range of clinical environments including the intensive care unit, interventional radiology, emergency room, and both preoperative and operating room environments. Data were collected from patients with brain injuries such as subarachnoid haemorrhage (N=44), traumatic brain injury (N=23), intraparenchymal haemorrhage (N=19), and ischemic stroke (N=22). OBPM was effectively used in patients undergoing surgical procedures such as open heart surgery (N=22), and carotid endarterectomy (N=11) as well as to continuously monitor post-surgical patients at risk of neurological injury. Furthermore, OBPM was effectively used concurrently with existing invasive and non-invasive neuromonitoring systems such as electroencephalography and bispectral index, demonstrating safe and effective real-time multimodal assessment strategy of cerebral function throughout a clinical care environment. 
Conclusion: OBPM experience in 195 patients has been shown to deliver consistent results with an unblemished safety record. Data drawn from the brain pulse monitor may improve clinical decision-making and bring significant clinical and economic value to healthcare stakeholders.

Photoplethysmography, Neuromonitoring, Multimodal assessment, Near-infrared light, Brain monitoring